Extending Capability and Implementing a Web Interface for the XALT Software Monitoring Tool

As high performance computing centers evolve in terms of hardware, software, and user-base, the act of monitoring and managing such systems requires specialized tools. The tool discussed in this thesis is XALT, which is a collaborative effort between the National Institute for Computational Sciences and Texas Advanced Computing Center. XALT is designed to track link-time and job level information for applications that are compiled and executed on any Linux cluster, workstation, or high-end supercomputer. The key objectives of this work are to extend the existing functionality of XALT and implement a real-time web portal to easily visualize the tracked data. A prototype is developed to track function calls resolved by external libraries which helps software management. The web portal generates reports and metrics which would improve efficiency and effectiveness for an extensive community of stakeholders including users, support organizations, and development teams. In addition, we discuss use cases of interest to center support staff and researchers on identifying users based on given counters and generating provenance reports. This work details the opportunity and challenges to further push XALT towards becoming a complete package

SABMIS: sparse approximation based blind multi-image steganography scheme

We hide grayscale secret images into a grayscale cover image, which is considered to be a challenging steganography problem. Our goal is to develop a steganography scheme with enhanced embedding capacity while preserving the visual quality of the stegoimage as well as the extracted secret image, and ensuring that the stego-image is resistant to steganographic attacks. The novel embedding rule of our scheme helps to hide secret image sparse coefficients into the oversampled cover image sparse coefficients in a staggered manner. The stego-image is constructed by using the Alternating Direction Method of Multipliers (ADMM) to solve the Least Absolute Shrinkage and Selection Operator (LASSO) formulation of the underlying minimization problem. Finally, the secret images are extracted from the constructed stego-image using the reverse of our embedding rule. Using these components together, to achieve the above mentioned competing goals, forms our most novel contribution. We term our scheme SABMIS (Sparse Approximation Blind Multi-Image Steganography). We perform extensive experiments on several standard images. By choosing the size of the length and the width of the secret images to be half of the length and the width of cover image, respectively, we obtain embedding capacities of 2 bpp (bits per pixel), 4 bpp, 6 bpp, and 8 bpp while embedding one, two, three, and four secret images, respectively. Our focus is on hiding multiple secret images. For the case of hiding two and three secret images, our embedding capacities are higher than all the embedding capacities obtained in the literature until now (3 times and 6 times than the existing best, respectively). For the case of hiding four secret images, although our capacity is slightly lower than one work (about 2/3rd), we do better on the other two goals (quality of stego-image & extracted secret image as well as resistance to steganographic attacks). For our experiments, there is very little deterioration in the quality of the stego-images as compared to their corresponding cover images. Like all other competing works, this is supported visually as well as over 30 dB of Peak Signal-to-Noise Ratio (PSNR) values. The good quality of the stego-images is further validated by multiple numerical measures. None of the existing works perform this exhaustive validation. When using SABMIS, the quality of the extracted secret images is almost same as that of the corresponding original secret images. This aspect is also not demonstrated in all competing literature. SABMIS further improves the security of the inherently steganographic attack resistant transform based schemes. Thus, it is one of the most secure schemes among the existing ones. Additionally, we demonstrate that SABMIS executes in few minutes, and show its application on the real-life problems of securely transmitting medical images over the internet

Role of nutritional supplements in the management of tendinopathies: focus on combination of type 1 collagen, vitamin C and mucopolysaccharides

Tendinopathy is a common disease that is difficult to manage due to its recurrent nature. It is associated with increased healthcare costs and significantly impacts quality of life of patients. Also, according to recent studies patients with high cholesterol and diabetes are at a higher risk of developing tendinopathy. There has been rise in the incidence of tendinopathies due to increase in sport activities, life expectancy and some other factors (environment, diet and some drug therapies). Approximately 30% of visits for musculoskeletal pain in general practice are related to tendon injury. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids remain the mainstay of treatment. Despite the use of current therapies, there is need of a supportive therapy that can help in the healing process towards development of physiologically normal tendons. Nutraceuticals have been used as supportive therapy for management of tendinopathies. This review focuses on the management of tendinopathy with special attention on role of nutraceuticals such as type I collagen, mucopolysaccharides and vitamin C in the management of tendinopathy. Clinical data suggests that this combination (type I collagen, mucopolysaccharides and vitamin C) promotes the endogenous synthesis of collagen type I, avoiding the accumulation of collagen type III and aggrecan, thus interfering with the degeneration of tendon tissue. Based on the available clinical data, combination of type I collagen, mucopolysaccharides and vitamin C not only reduce the clinical symptoms but also improve structural evolution of different types of tendinopathies as well as plantar fascitis

Impact of institutional educational program on compliance of implementation of surviving sepsis campaign guidelines, total ICU and hospital mortality

Background: To determine whether educational program based on the surviving sepsis campaign (SSC) guidelines affects the compliance of implementation of SSC guidelines, total ICU and hospital mortality.Methods: A prospective observational study conducted in adult patients with severe sepsis or septic shock admitted to 11 bedded adult medical and surgical ICU of Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India. In pre-education period all patients in ICU were daily screened according to severe sepsis screening tool and followed up daily during their entire period of ICU stay. Outcome measures were compliance of implementation of SSC guidelines, total ICU and hospital mortality noted. Education program of resident doctors of the ICU, emergency department, medical and surgical units was carried out. Post-education period data noted similar to the pre-education period. Comparative statistics applied by using Chi-square test and paired Student t-test.Results: Compliance to all resuscitative measures in SSC guideline both 3 hour and 6 hour bundles significantly improved after education program (P-value 0.014). In pre-education period 33.3% patients were treated with complete implementation of SSC Guidelines Bundles compared to 63.6% in post-education period. Total ICU mortality and hospital mortality did not change significantly after education program during study period. Total ICU mortality during pre-education period was 29.52% as compared to 25.45% in post-education period (P-value 0.44) while total hospital mortality in pre-education period was 5.18% as compared to 5.62% in post-education period (P-value 0.07).Conclusions: The Institutional educational program has significant impact on increasing compliance to both 3 hour and 6 hour bundles in SSC guideline but failed to show any significant impact on decreasing overall total ICU and hospital mortality

Spinal cord atrophy and myelomalacia following triple intrathecal chemotherapy in a patient of relapsed acute lymphoblastic leukemia

Paraplegia in a case of leukemia is an uncommon finding. It can be disease related, therapy related, or both. It may or maynot be reversible or curable. Here, we are discussing an unusual acute life-threatening, therapy related condition, where tripleintrathecal therapy in a relapsed acute lymphoblastic leukemia child led to severe spinal cord atrophy and myelomalacia causingacute paraplegia with urinary retention. Subsequently, the patient developed respiratory failure and succumbed to death. There isvery few case reported of this complication. The aim of this case report is to sensitize, the pediatricians and pediatric oncologistsabout this life-threatening complication of chemotherapy

Online refurbishment of old transformers

This article focuses on refurbishment / reconditioning for extension of life-expectancy of old transformers of EHV (extra high voltage 66 kV class and above) class, which were continuously in service for more than 20 years in the State Transmission Utility of Madhya Pradesh in India. The salient feature of this article for moisture refurbishment of old transformers was by adopting the criterion “% relative saturation of water in oil.” This selection criterion is different from the conventional practice in vogue of observing the deterioration trend of IR (Insulation Resistance) and PI (Polarization Index) values and the DGA (Dissolved Gas Analysis), etc. The reconditioning of all such old EHV transformers, precisely 205 units, was taken up “online” in a big way, avoiding long downtimes and frequent load shedding, etc., keeping in view dissatisfaction amongst the consumers at large. This project was completed over a period of five years

Effect of temperature and time delay in centrifugation on stability of select biomarkers of nutrition and non-communicable diseases in blood samples

Introduction: Preanalytical conditions are critical for blood sample integrity and poses challenge in surveys involving biochemical measurements. A cross sectional study was conducted to assess the stability of select biomarkers at conditions that mimic field situations in surveys. Material and methods: Blood from 420 volunteers was exposed to 2 – 8 °C, room temperature (RT), 22 – 30 °C and > 30 °C for 30 min, 6 hours, 12 hours and 24 hours prior to centrifugation. After different exposures, whole blood (N = 35) was used to assess stability of haemoglobin, HbA1c and erythrocyte folate; serum (N = 35) for assessing stability of ferritin, C-reactive protein (CRP), vitamins B12, A and D, zinc, soluble transferrin receptor (sTfR), total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), tryglicerides, albumin, total protein and creatinine; and plasma (N = 35) was used for glucose. The mean % deviation of the analytes was compared with the total change limit (TCL), computed from analytical and intra-individual imprecision. Values that were within the TCL were deemed to be stable. Result: Creatinine (mean % deviation 14.6, TCL 5.9), haemoglobin (16.4%, TCL 4.4) and folate (33.6%, TCL 22.6) were unstable after 12 hours at 22- 30°C, a temperature at which other analytes were stable. Creatinine was unstable even at RT for 12 hours (mean % deviation: 10.4). Albumin, CRP, glucose, cholesterol, LDL, triglycerides, vitamins B12 and A, sTfR and HbA1c were stable at all studied conditions. Conclusion: All analytes other than creatinine, folate and haemoglobin can be reliably estimated in blood samples exposed to 22-30°C for 12 hours in community-based studies

Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000–18: a geospatial modelling study

Background: More than 3 billion people do not have access to clean energy and primarily use solid fuels to cook. Use of solid fuels generates household air pollution, which was associated with more than 2 million deaths in 2019. Although local patterns in cooking vary systematically, subnational trends in use of solid fuels have yet to be comprehensively analysed. We estimated the prevalence of solid-fuel use with high spatial resolution to explore subnational inequalities, assess local progress, and assess the effects on health in low-income and middle-income countries (LMICs) without universal access to clean fuels. Methods: We did a geospatial modelling study to map the prevalence of solid-fuel use for cooking at a 5 km × 5 km resolution in 98 LMICs based on 2·1 million household observations of the primary cooking fuel used from 663 population-based household surveys over the years 2000 to 2018. We use observed temporal patterns to forecast household air pollution in 2030 and to assess the probability of attaining the Sustainable Development Goal (SDG) target indicator for clean cooking. We aligned our estimates of household air pollution to geospatial estimates of ambient air pollution to establish the risk transition occurring in LMICs. Finally, we quantified the effect of residual primary solid-fuel use for cooking on child health by doing a counterfactual risk assessment to estimate the proportion of deaths from lower respiratory tract infections in children younger than 5 years that could be associated with household air pollution. Findings: Although primary reliance on solid-fuel use for cooking has declined globally, it remains widespread. 593 million people live in districts where the prevalence of solid-fuel use for cooking exceeds 95%. 66% of people in LMICs live in districts that are not on track to meet the SDG target for universal access to clean energy by 2030. Household air pollution continues to be a major contributor to particulate exposure in LMICs, and rising ambient air pollution is undermining potential gains from reductions in the prevalence of solid-fuel use for cooking in many countries. We estimated that, in 2018, 205 000 (95% uncertainty interval 147 000–257 000) children younger than 5 years died from lower respiratory tract infections that could be attributed to household air pollution. Interpretation: Efforts to accelerate the adoption of clean cooking fuels need to be substantially increased and recalibrated to account for subnational inequalities, because there are substantial opportunities to improve air quality and avert child mortality associated with household air pollution. Funding: Bill & Melinda Gates Foundation